Advancements in Novel Materials, Methods and Technologies for Oral and Maxillofacial Bone Defect Repair

Congcong Li; Jianing Nie; Lifang Feng

doi:10.6919/ICJE.202412_10(12).0015

Authors

Congcong Li
Jianing Nie
Lifang Feng

DOI:

https://doi.org/10.6919/ICJE.202412_10(12).0015

Keywords:

Oral and Maxillofacial Bone Defect Repair; Novel materials; New Methods.

Abstract

Oral and maxillofacial bone defects, resulting from trauma, congenital malformations, or surgical resections, present a significant challenge in the field of dentistry and craniofacial surgery. These defects not only compromise the patient’s aesthetics but also impair their functional capacities. The development of novel materials, techniques, and technologies has revolutionized the management of such defects, offering more effective and less invasive alternatives to traditional methods. This review aims to provide an overview of the latest advancements in the field, focusing on the properties, advantages, limitations, and clinical applications of emerging materials and techniques for oral and maxillofacial bone defect repair.

Downloads

Download data is not yet available.

References

[1] Fillingham Y, Jacobs J. Bone grafts and their substitutes. Bone Joint J, 2016, 98-B (1 Suppl A): 6-9.

[2] Ramanathan M, Shijirbold A, Okui T, et al. In Vivo Evaluation of Bone Regenerative Capacity of the Novel Nanobiomaterial: β-Tricalcium Phosphate Polylactic Acid-co-Glycolide (β-TCP/PLLA/PGA) for Use in Maxillofacial Bone Defects. NANOMATERIALS, 2024, 14(1):91.

[3] Henning S, Herbert A W, Christian D, et al. Mandibular bone repair by implantation of rhBMP-2 in a slow release carrier of polylactic acid--an experimental study in rats. Biomaterials, 2008, 29(1): 103-110.

[4] Lantz O, Menginlecreulx D, Schmidt F, et al. Preparation and characterization of the composites of amino-modified artificial jaw nano-hydroxyapatite/ polylactic acid. Chinese Journal of Tissue Engineering Research, 2022, 26(20): 3319-3326.

[5] Juan G G Q, Juan Y D R, Carlos A M V, et al. Critical-sized mandibular defect reconstruction using human dental pulp stem cells in a xenograft model-clinical, radiological, and histological evaluation, Oral and Maxillofacial Surgery, 2020, 24(4): 485-493.

[6] Daphne S, Harald E, Adib A H H, et al. Patient-specific beta-tricalcium phosphate scaffold for customized alveolar ridge augmentation: a case report: Case Report: patient-specific β-TCP scaffold for alveolar ridge CBR. International journal of implant dentistry, 2024, 10(1):21.

[7] Umrath F, Schmitt L F, Kliesch S M, et al. Mechanical and Functional Improvement of β-TCP Scaffolds for Use in Bone Tissue Engineering. Journal of functional biomaterials, 2023, 14(8): 427.

[8] Lee U. OR281 – reconstruction of facial bone defect using resorbable parient-specific three-dimensionally printed polycaprolactone/beta-tricalcium phosphate exterior scaffold and autogenous bone. International Journal of Oral and Maxillofacial Surgery, 2024, 52(2): 103-104.

[9] Zhu Hong, Lin Ziheng, Luan Qifei, et al. Angiogenesis-promoting composite TPMS bone tissue engineering scaffold for mandibular defect regeneration, International Journal of Bioprinting, 2024, 10(1): 459-476.

[10] Simon S, Elisabeth C, Séverine C, et al. An innovative 3D hydroxyapatite patient-specific implant for maxillofacial bone reconstruction: A case series of 13 patients. Journal of Cranio-Maxillofacial Surgery, 2024, 52(4): 420-431.

[11] Zhao B D, Hao X, Wang W X, et al. Single Immediate Implant Placement into Anterior Maxillary Sockets with Facial Bone Defects: A 5-Year Retrospective Study. The International journal of oral & maxillofacial implants, 2023, 38(2): 374-380.

[12] Roberto R, Elisabetta C, Fabrizio B, et al. The Use of Nano-Hydroxyapatite (NH) for Socket Preservation: Communication of an Upcoming Multicenter Study with the Presentation of a Pilot Case Report, Medicina (Kaunas, Lithuania), 2023, 59(11): 1978.

[13] Maarten V, Anne-Laure V, Joris G, et al. Reconstruction of Craniomaxillofacial Bone Defects with 3D-Printed Bioceramic Implants: Scoping Review and Clinical Case Series. Journal of clinical medicine, 2024, 13(10): 2805.

[14] Ma M R, Shen W J, Li B B, et al. Optimization of a concentrated growth factor/mesoporous bioactive glass composite scaffold and its application in rabbit mandible defect regeneration. Biomaterials Science, 2023, 11(18): 6357-6372.

[15] Miguel M V, Felipe C, Monserrat C, et al. Preparation and osteogenic properties of nanocomposite hydrogel beads loaded with nanometric bioactive glass particles. Biomedical materials (Bristol, England), 2021, 16(4): 045043.

[16] Ramsha I, nAns A R, Refik P, et al. Numerical study on effect of process parameters on material extrusion 3D printing (ME3DP) for porous bone tissue engineering scaffolds. Results in Engineering, 2024, 22: 102046.

[17] Xu X Y, Wang H, Zhang S L, et al. ECM-inspired 3D printed polyetherimide scaffold with Arg-Gly-Asp peptides for the improvement of bioactivity and osteogenic differentiation of osteoblasts. Materials Today Communications,2022, 30(Suppl C): 103166.

[18] Fang C C, Chou Y S, Lee T M, et al. The Uniform Distribution of Hydroxyapatite in a Polyurethane Foam-Based Scaffold (PU/HAp) to Enhance Bone Repair in a Calvarial Defect Model. International journal of molecular sciences, 2024, 25(12): 6440.

[19] Sadra M, Helia S H B, Hanieh N, et al. Application of Biodegradable Patient-Specific Scaffolds for Maxillofacial Bone Regeneration: A Scoping Review of Clinical Studies. British Journal of Oral and Maxillofacial Surgery, 2023, 61(9): 587-597.

[20] Michaela M, Céline T, Michael D W, et al. Patient-specific implants made of 3D printed bioresorbable polymers at the point-of-care: material, technology, and scope of surgical application, 3D printing in medicine, 2024, 10(1): 13.

[21] SunX D, Mao Y P, Liu B B, et al. Mesenchymal Stem Cell-Derived Exosomes Enhance 3D-Printed Scaffold Functions and Promote Alveolar Bone Defect Repair by Enhancing Angiogenesis. Journal of personalized medicine, 2023, 13(2): 180.

[22] Peña G, Gallego L, Redondo L M, Comparative analysis of plasma-derived albumin scaffold, alveolar osteoblasts and synthetic membrane in critical mandibular bone defects: An experimental study on rats. Journal of biomaterials applications, 2021, 36(3): 481-491.

[23] Shao X X, Wu Y L, Ding M C, et al. Strong and tough β-TCP/PCL composite scaffolds with gradient structure for bone tissue engineering: Development and evaluation. Ceramics International, 2024, 50(No.18Part A): 31905-31917.

[24] Park D H, Jun J H, Yun S H, et al. Semi-customized three-dimensional ultra-fine titanium meshes in guided bone regeneration for implant therapy in severe alveolar bone defect: a case report. International journal of implant dentistry, 2024, 10(1): 17.

[25] Do W S, Kim, Y G, Suh J Y, et al. Retrograde Study Using Radiographic Comparison of Bone Fill Observed after Guided Tissue Regeneration by the Type of Periodontal Bone Defect. APPLIED SCIENCES-BASEL, 2024, 14(1): 179.

[26] Fliefel R, Kühnisch J, Ehrenfeld M, et al. Gene Therapy for Bone Defects in Oral and Maxillofacial Surgery: A Systematic Review and Meta-Analysis of Animal Studies. Stem cells and development, 2017, 26(4): 215-230.

[27] Valeriya S K, Andrey V V, Tatiana B B, et al. Application of BMP-2 and its gene delivery vehicles in dentistry. The Saudi Dental Journal, 2024, 26(6): 855-862.

[28] Olga K, Anna Y, Sergey I, et al. Gene-Activated Materials in Regenerative Dentistry: Narrative Review of Technology and Study Results. International journal of molecular sciences, 2023, 24(22): 16250.

[29] Al-Hamad K A, Shanab H G, Gaballah O M, et al. Potential therapeutic applications of mesenchymal stem cells in the oral and maxillofacial tissues. European review for medical and pharmacological sciences, 2023, 27(13): 6006-6017.

[30] Mahvish W K, Naveed I, Muhammad S Z, et al. A resonance frequency analysis to investigate the impact of implant size on primary and secondary stability. Pakistan journal of medical sciences, 2024, 40(6): 1261-1266.

[31] Vincenzo M, Chiara C, Giacomo D, et al. Resonance Frequency Analysis to Assess the Stability of Immediate Implants: A Retrospective Clinical Trial. The International journal of periodontics & restorative dentistry, 2023, 43(4): e165-e172.

[32] Peter H, Edward M, Michael N, et al. A longitudinal analysis of the impact of nonsurgical and surgical treatment of peri-implantitis upon clinical parameters and implant stability quotient values. A 2-3-year follow-up. Clinical and experimental dental research, 202410(1): e833.

[33] Jie B M, Han B X, Yao B C, et al. Automatic virtual reconstruction of maxillofacial bone defects assisted by ICP (iterative closest point) algorithm and normal people database. Clinical Oral Investigations, 2022, 26(2): 2005-2014.

[34] Unger S, Benic G I, Ender A, et al. Computer-assisted bone augmentation, implant planning and placement: An in vitro investigation. Clinical oral implants research, 2023, 34(7): 719-726.