Ibuprofen Cocrystal Preparation and Structure Study Using Fluorescence Spectrometry
DOI:
https://doi.org/10.54691/sjt.v4i10.2490Keywords:
Ibuprofen; Nicotinamide; Saccharin; Succinic Acid; Cocrystal.Abstract
Ibuprofen (IBU) was cocrystallized with nicotinamide (NIC), saccharin (SAC) and succinic acid (SUC) using solvent evaporation method and grinding method. Ibuprofen cocrystals were characterized by FTIR, XRD to analyze crystalline structure. Fluorescence spectrometer (FS) was also applied to verify the formation of ibuprofen cocrystals. The formation of IBU-NIC cocrystal, IBU-SAC cocrystal and IBU-SUC cocrystal were demonstrated by IR character peaks shift and new XRD character peaks. Solution method can produce IBU cocrystal with higher purity. The change of maximal fluorescence emission wavelength and strength can be used to verify the formation of cocrystal.
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Shen Z., Xie C., Wei D , et al. Preparation of Ibuprofen-Nicotinamide Cocrystal and Its Solubility Measurement[J]. Chemical Industry and Engineering, 2014,31(1):38-42.
Zhang SH, Yang Z., Zhang Y., et al. Synthesis, Characterization and Physicochemical Properties of an Ibuprofen Pharmaceutical Cocrystal[J]. Structural Chemistry, 2020(8):1444-1450.
Qiao, N.; Li, M.; Schlindwein, W.; Malek, N.; Davies, A.; Trappitt, G. Pharmaceutical cocrystals: An overview. Int. J. Pharm., 2011, 419(1-2), 1-11.
Karimi-Jafari, M.; Padrela, L.; Walker, G.M.; Croker, D.M. Creating cocrystals: A review of pharmaceutical cocrystal preparation routes and applications. Cryst. Growth Des., 2018, 18(10), 6370- 6387.
Kumar, S.; Nanda, A. Pharmaceutical cocrystals: An overview. Indian J. Pharm. Sci., 2017, 79, 858-871.
Douroumis, D.; Ross, S.A.; Nokhodchi, A. Advanced methodologies for cocrystal synthesis. Adv. Drug Deliv. Rev., 2017, 117, 178- 195.
Shaikh, R.; Singh, R.; Walker, G.M.; Croker, D.M. Pharmaceutical cocrystal drug products: An outlook on product development. Trends Pharmacol. Sci., 2018, 39(12), 1033-1048.
Pawar, N.; Saha, A.; Nandan, N.; Parambil, J.V. Solution cocrystallization: A scalable approach for cocrystal production. Crystals (Basel), 2021, 11(3), 303.
Panzade, P.; Shendarkar, G. Design and preparation of zaltoprofennicotinamide pharmaceutical cocrystals via liquid assisted grinding method. Indian J. Pharm. Educ. Res., 2019, 53(4), S563-S570.
Frisˇcˇic´ T, and Jones W. Recent advances in understanding the mechanism of cocrystal formation via Grinding [J]. Cryst Growth Des, 2009, 9(3):1621-1637.
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