Preparation, Solubilization and Content Determination of Silibinin-protamine Complex

Yamin Chang; Jianhao Wang

doi:10.6911/WSRJ.202408_10(8).0006

Authors

Yamin Chang
Jianhao Wang

DOI:

https://doi.org/10.6911/WSRJ.202408_10(8).0006

Keywords:

Silibinin; Alcoholic liver disease; Protamine; Improve bioavailability.

Abstract

With the increase in alcohol production and the drinking population, the incidence of alcoholic liver disease has risen rapidly, and it has become the second largest liver disease after viral hepatitis. This grim situation poses a serious threat to human health. Silibinin has biological functions such as protecting the liver from damage, improving kidney function, inhibiting myocardial damage, and so on. It has strong antioxidant activity and can effectively eliminate free radicals in the human body. However, its poor water solubility leads to low bioavailability, which limits its application in clinical medication to some extent. In this study, the solubility of silibinin in protamine was improved using solid dispersion technology, and its content was determined by high-performance liquid chromatography, in order to provide a new method for the research and development of silibinin drugs to improve bioavailability.

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