Changes of Platelet Parameters before and after Surgery in Patients with Subarachnoid Hemorrhage


  • Jinglian Zhou



Subarachnoid Hemorrhage; Surgery; Platelets.


Objective  To analyze the clinical application value of platelet parameter changes before and after surgery in patients with subarachnoid hemorrhage in our hospital, and to provide basis for clinical condition observation. Methods A total of 354 patients with subarachnoid hemorrhage who were hospitalized in our hospital from January 2017 to July 2021 were selected, and compared with 217 healthy individuals during the same period. The 4 parameters in platelet venous blood before and after surgery were analyzed: platelet count (Plt), mean platelet volume (MPV), platelet volume (PCT), and platelet distribution density (PDW). Results Before operation: Platelet count (PLT) decreased compared with the normal control group (p<0.01), MPV and PDW were increased compared with the normal control group (p<0.01); PLT increased after operation (p<0.01), but higher than that of the normal control group. Conclusions Early surgical treatment of aneurysmal subarachnoid hemorrhage can seal the ruptured blood vessel, reduce the exposure of endothelial cells, inhibit platelet activation, and reduce the formation of microthrombi.


Download data is not yet available.


Shutao Suo, Niu Di. The value of clipping and embolization in the treatment of intracranial aneurysm subarachnoid hemorrhage [J]. Shanxi Medical Journal, 2020,49(3):275-277.

Lublinsky S, Major S, Kola V,et al. Early blood-brain barrier dysfunction predicts neurological outcome following aneurysmal subarachnoid hemorrhage[J].EBio Med,2019,43(5):460-472.

Geraghty JR, Testai FD. Delayed cerebral ischemia after subarachnoid hemorrhage:beyond vasospasm and towards a multifactorial pathophysiology[J].Curr Atheroscler Rep,2017,19(12):50.

Suzuki S, Suzuki M, Iwabuchi T,et al.Role of multiple cerebral microthrombosis in symptomatic cerebral vasospasm:with a case report[J].Neurosurgery,1983,13(2):199-203.

Vergouwen MD, Vermeulen M,Coert BA,et al.Microthrombosis after aneurysmal subarachnoid hemorrhag:an additional explanation for delayed cerebral ischemia[J].J Cereb Blood Flow Metab, 2008, 28(11):1761-1770.

Neurology Branch of Chinese Medical Association, Cerebrovascular Disease Group of Neurology Branch of Chinese Medical Association. Guidelines for the diagnosis and treatment of subarachnoid hemorrhage in China 2015 [J].

Du J, Wang Q,He B,et al. Association of mean platelet volume and platelet count with the development and prognosis of ischemic and hemorrhagic stroke [J].Int J Lab Hematol,2016, 38(3): 233-239.

Songdi Yang.Discussion on the correlation between the mean platelet volume and platelet distribution width and the changes in the condition of patients with cerebral hemorrhage [J]. International Journal of Laboratory Medicine, 2014, 35(12): 1634-1635.

Xiushi Wang, Xiaoyan Leng, Changjun Sun, et al.Changes of platelet parameters and lipoprotein (a) and C-reactive protein in patients with acute cerebral infarction[J]. Laboratory Medicine and Clinical, 2011, 8(4): 411-413.

Varasteh-Ravan HR,Ali-Hasan-Al-Saegh S,et al.Relationship of admission mean platlet volume, platelet distribution width and white blood cells with ST resolution in patients with acute ST segment elevation myocardial infarction treated with streptokinase without history of previous cardiovascular surgery[J]. Perspect Clin Res,2013,4(2):125-129.




How to Cite

Zhou, J. (2022). Changes of Platelet Parameters before and after Surgery in Patients with Subarachnoid Hemorrhage. Frontiers in Science and Engineering, 2(12), 7–11.