Intervention of Vine Tea Extract on Non-alcoholic Fatty Liver in Mice
Keywords:Vine Tea Extract; High Fat Diet; Obesity; Oxidative Stress; Inflammatory Response.
To investigate the effects of vine tea extract (VTE) on high-fat-diet (HFD) induced obesity in mice. A C57BL/6J mouse model of obesity induced by 8-week high-fat diet was established. By measuring the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and the contents of triglyceride (TG), total cholesterol (T-CHO), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in serum. Pathological changes were observed by H&E staining to explore the effect of VTE on obese mice. The results showed that, compared with the model group, the levels of AST, ALT, TG, T-CHO, LDL-C in serum were significantly decreased, while the levels of HDL-C in serum was increased in the VTE low and high dose groups. It also improved fat vacuoles, inflammatory infiltration, and inflammatory response in liver tissue. In conclusion, VTE may improve lipid metabolism in HFD-induced obese mice by inhibiting oxidative stress and inflammatory response.
Jiang, S. Z., Lu, W., Zong, X. F., Ruan, H. Y., & Liu, Y. (2016). Obesity and hypertension. Experimental and therapeutic medicine, 12(4), 2395–2399. https://doi.org/10.3892/etm.2016.3667.
Martin, A., Saunders, D. H., Shenkin, S. D., & Sproule, J. (2014). Lifestyle intervention for improving school achievement in overweight or obese children and adolescents. The Cochrane database of systematic reviews, (3), CD009728. https://doi.org/10.1002/14651858.CD009728.pub2.
Karam J. H. (1992). Type II diabetes and syndrome X. Pathogenesis and glycemic management. Endocrinology and metabolism clinics of North America, 21(2), 329–350.
Di Berardino, C., Peserico, A., Capacchietti, G., Zappacosta, A., Bernabò, N., Russo, V., Mauro, A., El Khatib, M., Gonnella, F., Konstantinidou, F., Stuppia, L., Gatta, V., & Barboni, B. (2022). High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models. Nutrients, 14(20), 4341. https://doi.org/10.3390/nu14204341.
Xiao, F., Qiu, J., & Zhao, Y. (2022). Exploring the Potential Toxicological Mechanisms of Vine Tea on the Liver Based on Network Toxicology and Transcriptomics. Frontiers in pharmacology, 13, 855926. https://doi.org/10.3389/fphar.2022.855926.
Carneiro, R. C. V., Wang, H., Duncan, S. E., & O'Keefe, S. F. (2020). Flavor compounds in Vine Tea (Ampelopsis grossedentata) infusions. Food science & nutrition, 8(8), 4505–4511. https:// doi.org/ 10. 1002/fsn3.1754.
Shao, Q., Wu, Y., Ji, J., Xu, T., Yu, Q., Ma, C., Liao, X., Cheng, F., & Wang, X. (2021). Interaction Mechanisms Between Major Depressive Disorder and Non-alcoholic Fatty Liver Disease. Frontiers in psychiatry, 12, 711835. https://doi.org/10.3389/fpsyt.2021.711835.
Zhang, S., Wong, Y. T., Tang, K. Y., Kwan, H. Y., & Su, T. (2020). Chinese Medicinal Herbs Targeting the Gut-Liver Axis and Adipose Tissue-Liver Axis for Non-Alcoholic Fatty Liver Disease Treatments: The Ancient Wisdom and Modern Science. Frontiers in endocrinology, 11, 572729. https:// doi.org/ 10. 3389/fendo.2020.572729.
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