Study on the Preparation Process of Poly (L-lactic acid)-icariin Drug-loaded Microspheres

Xingyue Shuai; Ciwei Wang; Yan Zou; Yi Zhang; Rouchi Feng; Mengchun Qi

doi:10.6911/WSRJ.202504_11(4).0012

Authors

Xingyue Shuai
Ciwei Wang
Yan Zou
Yi Zhang
Rouchi Feng
Mengchun Qi

DOI:

https://doi.org/10.6911/WSRJ.202504_11(4).0012

Keywords:

o/w emulsification-solvent evaporation method; poly(L-lactic acid); Icariin; drug-loaded microspheres; encapsulation rate; drug-loading rate.

Abstract

The o/w type emulsification-solvent evaporation method was utilised to prepare the drug-carrying microspheres, with dichloromethane designated as the solvent phase, poly-L lactic acid as the carrier material, Icariin as the encapsulated drug, and Tween-80 as the emulsifier. The effects of ultrasonic time, ultrasonic power, volume ratio of internal and external phases, and dosage of poly-L lactic acid on the particle size, encapsulation rate, and drug loading rate of drug-carrying microspheres were explored during the preparation process of drug-carrying microspheres. The morphology of the drug-carrying microspheres was characterised by scanning electron microscopy, and the particle size and polydispersity index of the microspheres were characterised by nano-laser particle sizer. The optimal preparation of the drug-carrying microspheres was obtained as follows: The optimal parameters for the preparation of the drug-carrying microspheres were identified as follows: a Tween-80 concentration of 10 mg/mL, a poly(L-lactic acid) concentration of 25 mg/mL, an oil-to-water phase volume ratio of 1:2, an ultrasonic time of 15 min, and an ultrasonic power of 180 W.The drug-carrying microspheres of poly(L-lactic acid) were produced with a smaller particle size and better dispersion, and the encapsulation rate was 88.65%. The present study has the potential to furnish technical and parametric assistance for the fabrication of poly(L-lactic acid) drug-loaded slow-release microspheres.

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