Risk Factors and Management of Long COVID

Authors

  • Xiangmin Dong

DOI:

https://doi.org/10.54691/bcpep.v7i.2702

Keywords:

Long COVID; Risk Factors; Managements.

Abstract

The COVID-19 pandemic has been spreading around the world and cause serious harm to individual health and social development. Although we have established a comparatively perfect epidemic prevention system and medical system against SARS-CoV-2. Recent research suggests the emergence of a novel syndrome known as 'long COVID', a term used to describe a diverse set of symptoms that persist after a minimum of 4 weeks from the onset of a diagnosed SARS-CoV-2 infection. Like COVID-19, long COVID affect multiple organs and many systems including, but not limited to, the neurological, respiratory, gastrointestinal, cardiovascular and musculoskeletal systems. However, the exact factors leading to the long COVID-19 are not clear at present. This review summarizes many potential risk factors linked long COVID found in some papers, includingage, gender, symptom experienced and comorbidity. Preliminary evidences also suggest physical therapy (respiratory support in the ICU, evaluation and dietary approaches), protect mental health (government and social help) and gain social support can help mitigate long COVID.

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References

World Health Organization (2021) A clinical case definition of post COVID-19 condition by Delphi consensus, 6 October 2021. Available from: https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1.

McIntosh K, Hirsch M S, Bloom A. COVID-19: Clinical features[J]. UpToDate. Post TW (ed): UpToDate, Waltham, MA, 2021.

César Fernández-de-las-Peñas, Domingo Palacios-Ceña, Víctor Gómez-Mayordomo, Lidiane L Florencio, María L. Cuadrado, Gustavo Plaza-Manzano, Marcos Navarro-Santana, Prevalence of post-COVID-19 symptoms in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis, European Journal of Internal Medicine, Volume 92, 2021, Pages 55-70, ISSN 0953-6205.

Han Q, Zheng B, Daines L, Sheikh A. Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of One-Year Follow-Up Studies on Post-COVID Symptoms. Pathogens. 2022; 11(2):269. https://doi.org/10.3390/pathogens11020269.

Verity R, Okell LC, Dorigatti I, et al. Estimates of the severity of coronavirus disease 2019: a model-based analysis. Lancet Infect Dis. 2020;20(6):669–677. Doi: 10.1016/S1473-3099(20)30243-7.

Carvalho-Schneider C, Laurent E, Lemaignen A, et al. Follow-up of adults with noncritical COVID-19 two months after symptom onset. Clin Microbiol Infect. DOI: 10.1016/j.cmi.2020.09.052.

Jessica Seeßle, Tim Waterboer, Theresa Hippchen, Julia Simon, Marietta Kirchner, Adeline Lim, Barbara Müller, Uta Merle, Persistent Symptoms in Adult Patients 1 Year After Coronavirus Disease 2019 (COVID-19): A Prospective Cohort Study, Clinical Infectious Diseases, Volume 74, Issue 7, 1 April 2022, Pages 1191–1198, https://doi.org/10.1093/cid/ciab611.

Fernández-de-las-Peñas, C.; Martín-Guerrero, J.D.; Pellicer-Valero, Ó.J.; Navarro-Pardo, E.; Gómez-Mayordomo, V.; Cuadrado, M.L.; Arias-Navalón, J.A.; Cigarán-Méndez, M.; Hernández-Barrera, V.; Arendt-Nielsen, L. Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study. J. Clin. Med. 2022, 11, 413. https://doi.org/10.3390/jcm11020413.

Zhang, X.; Wang, F.; Shen, Y.; Zhang, Z.; Cen, Y.; Wang, B.; Zhao, S.; Zhou, Y.; Hu, B.; Wang, M.; et al. Symptoms and health outcomes among survivors of COVID-19 infection 1 year after discharge from hospitals in Wuhan, China. JAMA Netw. Open 2021, 4, e2127403.

Munblit, D.; Bobkova, P.; Spiridonova, E.; Shikhaleva, A.; Gamirova, A.; Blyuss, O.; Nikita Nekliudov, N.; Bugaeva, P.; Andreeva, M.; DunnGalvin, A.; et al. Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19. Clin. Exp. Allergy 2021, 51, 1107–1120.

Sigfrid, L.; Drake, T.M.; Pauley, E.; Jesudason, E.C.; Olliaro, P.; Lim, W.S.; Gillesen, A.; Berry, C.; Lowe, D.J.; McPeake, J.; et al. Long COVID in adults discharged from UK hospitals after COVID-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. Lancet Reg. Health Eur. 2021, 8, 100186.

Sudre CH, Murray B, Varsaysky T, et al. Attributes and predictors of Long-COVID: analysis of COVID cases and their symptoms collected by the COVID symptoms study app. medRxiv. 2020.

Md. Abdul Barek, Md. Abdul Aziz, Mohammad Safiqul Islam, Impact of age, sex, comorbidities and clinical symptoms on the severity of COVID-19 cases: A meta-analysis with 55 studies and 10014 cases, Heliyon, Volume 6, Issue 12, 2020, e05684, ISSN 2405-8440, https:// doi.org/ 10.1016/ j. heliyon. 2020. e05684. (https://www.sciencedirect.com/science/article/pii/S2405844020325275).

Francesca Bai, Daniele Tomasoni, Camilla Falcinella, Diletta Barbanotti, Roberto Castoldi, Giovanni Mulè, Matteo Augello, Debora Mondatore, Marina Allegrini, Andrea Cona, Daniele Tesoro, Gianmarco Tagliaferri, Ottavia Viganò, Elisa Suardi, Camilla Tincati, Tomaso Beringheli, Benedetta Varisco, Chiara Luridiana Battistini, Kyrie Piscopo, Elena Vegni, Alessandro Tavelli, Stefano Terzoni, Giulia Marchetti, Antonella d’Arminio Monforte,Female gender is associated with long COVID syndrome: a prospective cohort study,Clinical Microbiology and Infection,Volume 28, Issue 4, 2022, Pages 611.e9-611.e16, ISSN 1198-743X, https://doi.org/10.1016/j.cmi.2021.11.002.

César Fernández-de-las-Peñas, Oscar J. Pellicer-Valero, Esperanza Navarro-Pardo, Domingo Palacios-Ceña, Lidiane L. Florencio, Carlos Guijarro, José D. Martín-Guerrero, Symptoms Experienced at the Acute Phase of SARS-CoV-2 Infection as Risk Factor of Long-term Post-COVID Symptoms: The LONG-COVID-EXP-CM Multicenter Study, International Journal of Infectious Diseases, Volume 116, 2022, Pages 241-244, ISSN 1201-9712, https://doi.org/10.1016/j.ijid.2022.01.007. (Https:// www. sciencedirect. com/science/article/pii/S1201971222000078).

Louis Jacob, Ai Koyanagi, Lee Smith, Christian Tanislav, Marcel Konrad, Susanne van der Beck, Karel Kostev, Prevalence of, and factors associated with, long-term COVID-19 sick leave in working-age patients followed in general practices in Germany, International Journal of Infectious Diseases, Volume 109, 2021, Pages 203-208, ISSN 1201-9712, https://doi.org/10.1016/j.ijid.2021.06.063. (Https:// www. sciencedirect. com/science/article/pii/S120197122100552X).

Long-term COVID-19 symptoms in a large unselected population Elizabeth T. Cirulli, Kelly M. Schiabor Barrett, Stephen Riffle, Alexandre Bolze, Iva Neveux, Shaun Dabe, Joseph J. Grzymski, James T. Lu, Nicole L. Washington medRxiv 2020.10.07.20208702; doi: https:// doi.org/ 10.1101/ 2020. 10.07. 2020 8702.

Stavem K, Ghanima W, Olsen MK, et al. 1.5-6 months after COVID-19 in non-hospitalised subjects: a population-based cohort study. Thorax. 2021;76(4):405.

Bowles KH, McDonald M, Barrón Y, Kennedy E, O'Connor M, Mikkelsen M. Surviving COVID-19 After Hospital Discharge: Symptom, Functional, and Adverse Outcomes of Home Health Recipients. Ann Intern Med. 2021 Mar;174(3):316-325. Doi: 10.7326/M20-5206. Epub 2020 Nov 24. PMID: 33226861; PMCID: PMC7707212. Malik, P, Patel, K, Pinto, C, et al. Post-acute COVID-19 syndrome (PCS) and health-related quality of life (HRQoL)--A systematic review and meta-analysis. J Med Virol. 2021; 94: 253- 262.

Qiutang Xiong, Ming Xu, Jiao Li, Yinghui Liu, Jixiang Zhang, Yu Xu, Weiguo Dong, Clinical sequelae of COVID-19 survivors in Wuhan, China: a single-centre longitudinal study, Clinical Microbiology and Infection, Volume 27, Issue 1, 2021, Pages 89-95, ISSN 1198-743X.

Malik, P, Patel, K, Pinto, C, et al. Post-acute COVID-19 syndrome (PCS) and health-related quality of life (HRQoL)--A systematic review and meta-analysis. J Med Virol. 2021; 94: 253- 262. https:// doi.org/ 10.1002/ jmv.27309.

Candan, SA, Elibol, N, Abdullahi, A. Consideration of prevention and management of long-term consequences of post-acute respiratory distress syndrome in patients with COVID-19. Physiother Theory Pract 2020; 36: 663–668.

Piotrowicz, K., Gąsowski, J., Michel, JP. et al. post-COVID-19 acute sarcopenia: physiopathology and management. Aging Clin Exp Res 33, 2887–2898 (2021). https://doi.org/10.1007/s40520-021-01942-8.

Mikkelsen, M. E., & Abramoff, B. COVID-19: evaluation and management of adults with persistent symptoms following acute illness (“Long COVID”). UpToDate. Updated July 19, 2022.

Liu K, Zhang W, Yang Y, Zhang J, Li Y, Chen Y. Respiratory rehabilitation in elderly patients with COVID-19: A randomized controlled study. Complement Ther Clin Pract. 2020 May; 39:101166. doi: 10.1016/j.ctcp.2020.101166. Epub 2020 Apr 1. PMID: 32379637; PMCID: PMC7118596.

Aiyegbusi OL, Hughes SE, Turner G, et al. Symptoms, complications and management of long COVID: a review. Journal of the Royal Society of Medicine. 2021;114(9):428-442.

Sanaz Shanbehzadeh, Mahnaz Tavahomi, Nasibeh Zanjari, Ismail Ebrahimi-Takamjani, Somayeh Amiri-arimi, Physical and mental health complications post-COVID-19: Scoping review, Journal of Psychosomatic Research, Volume 147, 2021, 110525, ISSN 0022-3999, https:// doi.org/ 10. 1016/j. jpsychores. 2021.110525.

Garrigues, E, Janvier, P, Kherabi, Y, et al. post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19. J Infect 2020; 81: e4–e6.

Azzolini E, Levi R, Sarti R, Pozzi C, Mollura M, Mantovani A, Rescigno M. Association Between BNT162b2 Vaccination and Long COVID After Infections Not Requiring Hospitalization in Health Care Workers. JAMA. 2022 Aug 16;328(7):676-678. Doi: 10.1001/jama.2022.11691. PMID: 35796131; PMCID: PMC9250078.

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Published

2022-11-07

How to Cite

Dong, X. . (2022). Risk Factors and Management of Long COVID. BCP Education & Psychology, 7, 444–448. https://doi.org/10.54691/bcpep.v7i.2702