Research Progress on Mo-based Two-dimensional Materials in Non-enzymatic Glucose Sensors

Siyuan Jin

doi:10.6919/ICJE.202504_11(4).0016

Authors

Siyuan Jin

DOI:

https://doi.org/10.6919/ICJE.202504_11(4).0016

Keywords:

Non-enzymatic Sensors; Two-dimensional Materials; Glucose Detection; Electrocatalysis; Mo-based Materials.

Abstract

This article simply reviews the research progress of non-enzymatic glucose sensors based on two-dimensional Mo-based materials (MoS₂, MoO₃, MoSe₂), with a focus on analyzing their electrocatalytic mechanisms, performance optimization strategies, and application potential. By comparing the sensitivity, detection limit, and stability of different materials, the advantages of molybdenum-based two-dimensional materials in sensor design are summarized. Furthermore, emerging applications in medical health, smart wearables, and environmental monitoring are discussed, and future research directions are proposed, including the development of multifunctional composite materials and breakthroughs in miniaturization technology. Finally, the future development of molybdenum-based non-enzymatic glucose sensors is prospected.

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References

[1] Jasrotia R, Raj K, Singh B, et al. Innovative ferrite sensors: Advancing non-enzymatic glucose detection. Sensors and Actuators Reports, 2025, 100295.

[2] Yoo J, Kim IT, Park JY, et al. Electrochemical glucose sensor based on a phenothiazine derivative mediator with nicotinamide adenine dinucleotide-dependent glucose dehydrogenase. Sens Actuators B Chem, 2025, 422.

[3] Shahzad U, Saeed M, Marwani HM, et al. Recent progress on potentiometric sensor applications based on nanoscale metal oxides: A comprehensive review. Crit Rev Anal Chem, 2024, 1–18.

[4] Wu Y, Gao T, Ren HT, et al. Photoexcited CuO/TiO₂ heterojunction for photoelectrochemical sensors for nonenzymatic glucose detection. Langmuir, 2025, 41(2): 1526–1535.

[5] Osuna V, Aparicio Martínez EP, Dominguez RB, et al. A review on the advances in nanomaterials for electrochemical non-enzymatic glucose sensors working in physiological conditions. Chemosensors, 2024, 12: 159.

[6] Huang C, Zhang M, Li C. A novel non-enzymatic electrochemical glucose sensor based on graphene oxide nanoribbons: tracking energy expenditure and nutritional intake in sports. Alex Eng J, 2024, 89: 184–194.

[7] Shao Z, Gao Q, Sun S, et al. MOF-derived CuO/CNT for high sensitivity and fast response glucose sensing. Sens Actuators B Chem, 2024, 398.

[8] Baruah S, Mohanta D, Betty CA. Composite PEDOTPSS based highly sensitive electrochemical sensors for sensing glucose from human saliva. Microchem J, 2024, 206.

[9] Kiranakumar HV, Thejas R, Naveen CS, et al. A review on electrical and gas-sensing properties of reduced graphene oxide-metal oxide nanocomposites. Biomass Convers Biorefin, 2024, 14: 12625–12635.

[10] Zhu H, Li L, Zhou W, et al. Advances in non-enzymatic glucose sensors based on metal oxides. Journal of Materials Chemistry B, 2016, 46: 175.

[11] Singh K, Maurya KK, Malviya M. Recent progress on nanomaterial-based electrochemical sensors for glucose detection in human body fluids. Microchim Acta, 2025, 192: 110.

[12] Pletcher D. Electrocatalysis: Present and future. J. Appl Electrochem., 1984, 14: 403–415.

[13] Wang SF, Xu Q .Electrochemical parameters of ethamsylate at multi-walled carbon nanotube modified glassy carbon electrodes. Bioelectrochemistry, 2007, 70: 296–300.

[14] Li H, Xiao N, Jiang M, et al. Advances of transition metal-based electrochemical non-enzymatic glucose sensors for glucose analysis: A review. Critical Reviews in Analytical Chemistry, 2024.

[15] Huang JW, Dong ZP, Li YR, et al. MoS₂ nanosheet functionalized with Cu nanoparticles and its application for glucose detection. Mater. Res. Bull., 2013, 48(11): 4544–4547.

[16] Huang JW, He YQ, Jin J, et al. A novel glucose sensor based on MoS₂ nanosheet functionalized with Ni nanoparticles. Electrochim. Acta, 2014, 136: 41–46.

[17] Luo Y, Xiang Y, Qin L, et al. Screen-printed electrode modified with MoO₃-MoS₂/Ni porous array for sensitive non-enzymatic glucose sensor. Sensors and Actuators A: Physical, 2023, 364: 114817.

[18] Ma K, Sinha A, Dang X, et al. Electrochemical preparation of gold nanoparticles-polypyrrole co-decorated 2D MoS₂ nanocomposite sensor for sensitive detection of glucose. J Electrochem Soc, 2019, 166(2): B147.

[19] Ravitchandiran A, AlGarni S, AlSalhi MS, et al. ZnFe(PBA)@Ti₃C₂Tx nanohybrid-based highly sensitive non-enzymatic electrochemical sensor for the detection of glucose in human sweat. Sci Rep, 2024, 14: 23835.

[20] Wang C, Yang X, Zhu G, et al. One-step synthesis of copper-platinum nanoparticles modified electrode for non-enzymatic salivary glucose detection. Colloids Surf A Physicochem Eng Asp, 2023, 658.

[21] Zhang S, Zhang W, Lou Y, et al. Fabrication of Ni–Mo–Nb metallic glass/micro-nano lattice composite for nonenzymatic glucose sensing. Progress in Natural Science: Materials International, 2023, 33(5): 601-606.

[22] Ravitchandiran A, AlGarni S, AlSalhi MS, et al. ZnFe(PBA)@Ti₃C₂Tx nanohybrid-based highly sensitive non-enzymatic electrochemical sensor for the detection of glucose in human sweat. Sci Rep, 2024, 14: 23835.

[23] Shan J, Li J, Chu X, et al. High sensitivity glucose detection at extremely low concentrations using a MoS₂-based field-effect transistor. RSC Adv, 2018, 8(15): 7942–7948.

[24] Jeevanandham G, Vediappan K, AlOthman ZA, et al. Fabrication of 2D-MoSe₂ incorporated NiO Nanorods modified electrode for selective detection of glucose in serum samples. Sci Rep, 2021, 11: 13266.

[25] Chen R, Guo C, Lan G, et al. Highly sensitive surface plasmon resonance sensor with surface modified MoSe₂/ZnO composite film for non-enzymatic glucose detection. Biosensors and Bioelectronics, 2023, 237: 115469.

[26] Azharudeen AM, Karthiga R, Rajarajan M, et al. Selective enhancement of non-enzymatic glucose sensor by used PVP modified on α-MoO₃ nanomaterials. Microchemical Journal, 2020, 157: 105006.

[27] Ren H, Yan L, Liu M, et al. Green tide biomass templated synthesis of molybdenum oxide nanorods supported on carbon as efficient nanozyme for sensitive glucose colorimetric assay. Sens. Actuators B Chem., 2019, 296: 126517/1–126517/8.

[28] Salarizadeh N, Habibi-Rezaei M, Zargar SJ, et al. NiO–MoO₃ nanocomposite: A sensitive non-enzymatic sensor for glucose and urea monitoring. Materials Chemistry and Physics, 2022, 281: 125870.

[29] Sharma M, Gangan A, Chakraborty B, et al. Non-enzymatic glucose sensing properties of MoO₃ nanorods: Experimental and density functional theory investigations. J Phys D: Appl Phys, 2017, 50: 475401.

[30] Salarizadeh N, Habibi-Rezaei M, Zargar SJ, et al. NiO–MoO₃ nanocomposite: A sensitive non-enzymatic sensor for glucose and urea monitoring. Mater Chem Phys, 2022, 281: 125870.

[31] Kamble BB, Talele P, Tawade AK, et al. In situ soft templated synthesis of polyfluorene-molybdenum oxide (PF-MoO₃) nanocomposite: A nanostructure glucose sensor. Korean J Chem Eng, 2022, 39: 1604–1613.

[32] Sharma M, Gangan A, Chakraborty B, et al. Non-enzymatic glucose sensing properties of MoO₃ nanorods: Experimental and density functional theory investigations. J Phys D: Appl Phys, 2017, 50: 475401.

[33] Zhang S, Zhang W, Lou Y, et al. Fabrication of Ni–Mo–Nb metallic glass/micro-nano lattice composite for nonenzymatic glucose sensing. Progress in Natural Science: Materials International, 2023, 33(5): 601-606.

[34] Ravitchandiran A, AlGarni S, AlSalhi MS, et al. ZnFe(PBA)@Ti₃C₂Tx nanohybrid-based highly sensitive non-enzymatic electrochemical sensor for the detection of glucose in human sweat. Sci Rep, 2024, 14: 23835.

[35] Romeo A, Moya A, Leung TS, et al. Inkjet printed flexible non-enzymatic glucose sensor for tear fluid analysis. Appl Mater Today, 2018, 10: 133–141.

[36] Ting JH, Lin PC, Gupta S, et al. Dipole moment as the underlying mechanism for enhancing the immobilization of glucose oxidase by ferrocenechitosan for superior specificity non-invasive glucose sensing. Nanoscale Adv, 2023, 5: 4881–4891.

[37] Lin PH, Sheu SC, Chen CW, et al. Wearable hydrogel patch with noninvasive, electrochemical glucose sensor for natural sweat detection. Talanta, 2022, 241.

[38] Janyasupab M, Liu CW, Chanlek N, et al. A comparative study of nonenzymatic glucose detection in artificial human urine and human urine specimens by using mesoporous bimetallic cobalt-iron supported N-doped graphene biosensor based on differential pulse voltammetry. Sens Actuators B Chem, 2019, 286: 550–563.

[39] Chang M, Hao L, Li X, et al. Boosting the performance of enzyme-free biosensing system with Ni–Co bimetallic nanorod anchored on macroporous carbon composites for glucose monitoring. Mater Res Bull, 2024, 169.

[40] Wang C, Yang X, Zhu G, et al. One-step synthesis of copper-platinum nanoparticles modified electrode for non-enzymatic salivary glucose detection. Colloids Surf A Physicochem Eng Asp, 2023, 658.